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The older-model Ford Explorer Sport crashed in the left lane shortly before 5:30 p.m. before the Madison Avenue exit at mile marker 59.6, they said.
The New Jersey State Police Fatal Accident Investigations Unit was immediately summoned because of the initial severity of injuries.
The victim was pronounced dead shortly after 6 p.m.
City firefighters and police and a state DOT crew were among the responders joining NJ State Police troopers at the scene.
All lanes of the westbound highway were temporarily closed while the wreckage was cleared and detectives investigated.
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